Mode-Oligomer: Database of Normal Mode Analysis in Dihedral Angle Space for a Full-Atom System of Oligomeric Proteins

Wako, Hiroshi; Endo, Shigeru

ProMode-Oligomer: Database of Normal Mode Analysis in Dihedral Angle Space for a Full-Atom System of Oligomeric Proteins

Hiroshi Wako^{*, a}, Shigeru Endo^b

^a School of Social Sciences, Waseda University, Tokyo 169-8050, Japan

^b Department of Physics, School of Science, Kitasato University, Sagamihara 252-0373, Japan

Article Information

Identifiers and Pagination:

Year: 2012
Volume: 6
First Page: 9
Last Page: 19
Publisher ID: TOBIOIJ-6-9
DOI: 10.2174/1875036201206010009

Article History:

Received Date: 24/11/2011
Revision Received Date: 28/12/2011
Acceptance Date: 06/01/2012
Electronic publication date: 21/02/2012
Collection year: 2012

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© 2012 Wako and Endo

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

^* Address correspondence to this author at the School of Social Sciences, Waseda University, Tokyo 169-8050, Japan; Tel: +81-3-5286-1430; Fax: +81-3-5272-0168; E-mail: wako@waseda.jp

The database ProMode-Oligomer (http://promode.socs.waseda.ac.jp/promode_oligomer) was constructed by collecting normal-mode-analysis (NMA) results for oligomeric proteins including protein-protein complexes. As in the ProMode database developed earlier for monomers and individual subunits of oligomers (Bioinformatics vol. 20, pp. 2035–2043, 2004), NMA was performed for a full-atom system using dihedral angles as independent variables, and we released the results (fluctuations of atoms, fluctuations of dihedral angles, correlations between atomic fluctuations, etc.). The vibrating oligomer is visualized by animation in an interactive molecular viewer for each of the 20 lowest-frequency normal modes. In addition, displacement vectors of constituent atoms for each normal mode were decomposed into two characteristic motions in individual subunits, i.e., internal and external (deformation and rigid-body movements of the individual subunits, respectively), and then the mutual movements of the subunits and the movement of atoms around the interface regions were investigated. These results released in ProMode-Oligomer are useful for characterizing oligomeric proteins from a dynamic point of view. The analyses are illustrated with immunoglobulin light- and heavy-chain variable domains bound to lysozyme and to a 12-residue peptide.

Keywords: Normal mode analysis, Oligomer, Internal motion, External motion, Immunoglobulin, Lysozyme.

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RESEARCH ARTICLE

ProMode-Oligomer: Database of Normal Mode Analysis in Dihedral Angle Space for a Full-Atom System of Oligomeric Proteins

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