e-PROPAINOR: A Web-Server for Fast Prediction of Cα Structure & Likely Functional Sites of a Protein Sequence

Rajani R. Joshi*, N. T. Jyothish
Department of Mathematics, IIT Bombay, Powai, Mumbai: 400076 India.

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© 2010 Joshi and Jyothish

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Mathematics, IIT Bombay, Powai, Mumbai: 400076 India; Tel: +91-22-25767485; E-mail:


e-PROPAINOR ( is a web-server based on extension of PROPAINOR for prediction and computational function elucidation of 3-D structure of proteins. It predicts the Cα structure of a given protein sequence. Computational efficiency and reliability are key features of its software. Moreover, it also gives an estimate of the RMSD of the predicted structure. For the structures predicted with estimated RMSD of the order ≤ 5Å, it predicts likely sites of five major types of protein functions.

Keywords: Protein Structure prediction, Nonparametric regression, Nonparametric Discriminant analysis, Distance geometry.