A New Deep Learning Model based on Neuroimaging for Predicting Alzheimer's Disease

Kiran P.1, Sudheesh K. V.1, Vinayakumar Ravi2, *, Meshari Almeshari3, Yasser Alzamil3, Sunil Kumar D. S.4, Harshitha R.5
1 Department of ECE, Vidyavardhaka College of Engineering, Mysuru, India
2 Center for Artificial Intelligence, Prince Mohammad Bin Fahd University, Khobar, Saudi Arabia
3 Department of Diagnostic Radiology, College of Applied Medical Sciences, University of Ha'il, Ha'il, Saudi Arabia
4 Department of MCA, Administrative Management College, Bengaluru, India
5 Department of ECE, GSSS Institute of Engineering & Technology for Women, Mysuru, India

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© 2023 P. et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the enter for Artificial Intelligence, Prince Mohammad Bin Fahd University, Khobar, Saudi Arabia; E-mail:



The psychological aspects of the brain in Alzheimer's disease (AD) are significantly affected. These alterations in brain anatomy take place due to a variety of reasons, including the shrinking of grey and white matter in the brain. Magnetic resonance imaging (MRI) scans can be used to measure it, and these scans offer a chance for early identification of AD utilizing classification methods, like convolutional neural network (CNN). The majority of AD-related tests are now constrained by the test measures. It is, thus, crucial to find an affordable method for image categorization using minimal information. Because of developments in machine learning and medical imaging, the field of computerized health care has evolved rapidly. Recent developments in deep learning, in particular, herald a new era of clinical decision-making that is heavily reliant on multimedia systems.


In the proposed work, we have investigated various CNN-based transfer-learning strategies for predicting AD using MRI scans of the brain's structural organization. According to an analysis of the data, the suggested model makes use of a number of sites related to Alzheimer's disease. In order to interpret structural brain pictures in both 2D and 3D, the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset includes straightforward CNN designs based on 2D and 3D convolutions.


According to these results, deep neural networks may be able to automatically learn which imaging biomarkers are indicative of Alzheimer's disease and exploit them for precise early disease detection. The proposed techniques have been found to achieve an accuracy of 93.24%.


This research aimed to classify Alzheimer's disease (AD) using transfer learning. We have used strict pre-processing steps on raw MRI data from the ADNI dataset and used the AlexNet, i.e., Alzheimer's disease has been categorized using pre-processed data and the CNN classifier.

Keywords: Alzheimer’s disease, CNN, MRI, Amnesia, Medical image, Dataset.